Name: Joe Rogan Experience #502 - Dr. Rhonda Patrick
Uploaded: 2014-05-17T03:07:41.000Z
Description: Watch the stand-up comedy video 'Joe Rogan Experience #502 - Dr. Rhonda Patrick' from PowerfulJRE on Comedy Buff. Published 2014-05-17. Transcript available.

Watch the stand-up comedy video 'Joe Rogan Experience #502 - Dr. Rhonda Patrick' from PowerfulJRE on Comedy Buff. Published 2014-05-17. Transcript available.

Joe Rogan Experience #502 - Dr. Rhonda Patrick

oh hello freaks yes we are back again did you miss us no you couldn't have
missed us we've
been doing this shit all week this is ridiculous this is the longest run of
podcasts ever for me
where there's four of them in the top 10 right now yeah four out of this that's
crazy we have
four podcasts that sounds like bragging it's a lot of pressure for me this
episode no there's no
pressure dr. Patrick worry not this episode of the Joe Rogan Experience is
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today how about that cue the music
young Jamie talk to Rhonda Patrick is here we're gonna find some shit out about
health
Joe Rogan podcast check it out the Joe Rogan experience
train by day Joe Rogan podcast by night all day
hello Rhonda hello Joe you're the only person that's ever come in sat down and
said oh this is
good I'm getting a cortisol rush he said you're getting a cortisol rush from
the the feeling of
about to do yeah actually I could have gone a little more detail but as I do
yeah you
know so that feeling of anxiety you know that like you get before you get on
stage I
mean you're a comedian I'm sure you're really familiar with that you actually
are expressing
a chemical called dynorphin and this is an endogenous chemical in your brain
and it
binds to something called the kappa opioid receptor it's kind of like the
counter of the
endorphin which binds to the mu opioid receptor so the endorphins are the feel-good
well it's nemesis
is the dinorphin which is that anxiety like feeling so but here's the
interesting part that
anxiety like feeling that you feel before you're you know gonna do something
like you're you know
really that you care about or that's kind of anxiety provoking for me public
speaking does it
I get it right before I'm gonna do it you know give a talk or something or do a
podcast in front of you know
500,000 people so that dynorphin binding to the kappa opioid receptor what it
does is it up regulates
the mu opioid receptor so that after you get that anxiety feeling you have a
better endorphin rush
because you up regulate the mu opioid receptors which bind to the endorphins
the feel-good ones and
you actually become sensitized to them so there's a biological mechanism by
which having that anxiety
actually does you good so it's it's kind of like a stress at first but then
later on you're you get you
more relaxed that's amazing you know that's interesting because the one of the
best feelings
ever is after you compete like when you fight one of the things that people get
addicted to is you get
addicted to the rush for sure the adrenaline rush and you get addicted to the
just the the challenge of
competition being life magnified on such an incredible scale that everything
else seems kind of pale in
comparison but the big addiction i think is the feeling that you get after you
compete especially
if you win there's just amazing feeling like life is incredible you just you
you like the the ground
feels better under your feet the colors and the trees look better everything
looks better for a couple
days yeah no i totally know what you're talking about and there's a biological
mechanism for that and
it's interesting because it's also the same mechanism that occurs when you are
working out really hard i mean it's
painful while you're doing it but you the more pain you experience the better
the rush the better it's the endorphin high
people talk about it's actually that that mechanism is anxiety inducing stress
inducing is is an important
factor in that because of this mechanism i talk about where you up regulate
those receptors that bind to the
endorphins and you become and you're sensitizing them so they become more
sensitized to them so it's uh heat does the
same thing heat uh stress so you know exercise capsaicin so eating spicy food
it's painful while you're eating
it but what happens is there's you're up regulating those those new opioid
receptors and you're sensitizing
them to the endorphins which is why you feel really good after eating spicy
food oh that's what that
is yeah i never knew what that was that's interesting because i always thought
it just tasted good like
a kind of a weird cool good spicy taste i'm sure there's dopamine responses and
all that stuff involved
i mean there's you know complex mechanisms and things going on in your brain
but when you're eating or when you
you pleasure when you enjoy a certain taste of a food but this particular
mechanism where you've got this
dynorphin and endorphin you know connection um it's really interesting and i
think it's something i i
discussed in a recent article that i i wrote about the sauna so i hope you know
people find it interesting
because i think it's interesting it's not something people know about it it is
it's gotten some really
good responses too i've uh i've read it and i've read a lot of the responses
people found it pretty
fascinating when you were talking about in the podcast but it's kind of almost
like the yin and yang of
life is what you're talking about here it's like you need to have some negative
in order to feel some
extra positive right no the uh are you familiar with hormesis um i know i've
heard the term but i couldn't
describe it if somebody asked me to like so what it means you mean yes okay so
hormesis what it really
refers to is having a little bit of stress something that's a little toxic for
you something that's a
little stressful on your body i mean exercise for sure is that heat is a little
stressful things um in
some of the foods we eat like the egcgs and green tea or polyphenols and some
of the fruits and also in red wine
these things are actually a little bit toxic to our body and what happens is
that this induces um
stress response mechanisms in our body the activation of a whole host of genes
like you know antioxidant
genes glutathione peroxidase things like um you know heat shock factors which
do a variety of different
things so a little bit of stress activates this whole stress response mechanism
in our body and then what
happens is now we can deal with stress better so it's it's kind of like
interesting to think about
adding a little bit of something that's toxic to you know get a better response
that's fascinating you
were talking about that last time we were here about mycotoxins that in fact mycotoxins
in a small dose
might induce that sort of a response yeah i mean i totally made i was wet hand
waving i haven't read
anything i was hand waving i'm like well actually maybe um it makes sense that
in a small dose i mean
obviously you don't want something that's like very toxic and gonna kill your
brain cells or anything
like that but uh things in small doses and i was assuming that maybe mycotoxins
could possibly have a
little slight hormetic effect um you know like i said that was just me theorizing
uh you know so but
isn't it fascinating though that that is sort of the way like especially when
it comes to exercise
that you need to experience this like intense hardship in order to get this
wonderful feeling
of accomplishment this endorphin rush and this i feel so good after i work out
like i i make all my
best decisions after i have a really good workout it's just like my body has a
perspective i have a
better perspective if i haven't worked out in a couple of days and i'm stressed
and and then i have to
make a decision oftentimes i don't trust my judgment oh yeah i'm the same way i'm
absolutely uh addicted
to the the feeling and and the physiological changes that occur with exercise
and there are a lot of them
that are occurring um you know in the brain and elsewhere uh but it's the same
you know it's it what's
really kind of fascinating recently you know we you know about inducing neurogenesis
when you work
out that's kind of well known where exercise induces the growth of new brain
cells bdnf is one way igf1
these things can you know you grow new brain cells and so growing new brain
cells has always been
associated with um learning and memory it's like oh you grow new new brain
cells and and they've shown
that that neurogenesis in adults at least is associated with new learning and
new memory but
what they found recently and i found this really interesting um because it kind
of changed the way
i think of it uh is that when you grow those new brain cells like when you're
exercising um heat
stress does the same thing actually so getting in the sauna when you're
exercising your heat
stress in your body i mean your core body temperature is elevated it's you know
very similar um so what
happens is you grow new brain cells and these new brain cells have to make new
connections with other
neurons and so what what ends up happening is that other connections that you
made with so the connections
you make between neurons these synapses that you form memories it's things that
you can remember right i
mean you make you form these synapses and that's like a piece of information
remembered or in some cases it's a
an experience that you had that you remember well you actually change those synapses
and some of
them go away so you kind of forget to make room for a new neuron to make a new
so it it really is
interesting how also you have this connection but it's a balance where you're
forgetting things that
you're you're totally disconnecting some connections between old neurons that
you had previously made for whatever
thing you had learned or and you're making room for this new neuron that just
was born to make a new
connection and make learn something new so uh you have that balance again it's
just you know it's it
seems like a very important biological mechanism this this mean and yang where
it's like there's there's
stress and then there's the response to the stress which is good and you know
there's things like
you know forgetting things but so that you can learn new things i mean it's
kind of important can you
imagine if you remembered everything you've ever you'd go insane yeah i i have
a real problem with
that i have a real problem with uh having too much information in my head and
then forgetting things
that other people remember and they'll they'll remember it like it was this big
important thing
and i'm like what did we really do that i don't remember that and it's just
because i've had too many
experiences like there's too much stuff or if you go back to talk to someone
you went to high school with
people that don't leave that are stuck in that town and they they can remember
remember when we were 17
and we did that crazy thing like no i don't remember 