Name: Joe Rogan Experience #994 - Dom D'Agostino
Uploaded: 2017-08-08T00:56:58.000Z
Description: Watch the stand-up comedy video 'Joe Rogan Experience #994 - Dom D'Agostino' from PowerfulJRE on Comedy Buff. Published 2017-08-08. Transcript available.

Watch the stand-up comedy video 'Joe Rogan Experience #994 - Dom D'Agostino' from PowerfulJRE on Comedy Buff. Published 2017-08-08. Transcript available.

Joe Rogan Experience #994 - Dom D'Agostino

Boom and we're live. How are you, Dom? Welcome to the show. I'm doing great,
Joe. Pull this sucker right up close. There you go.
I know you've done the podcast before. You did Tim Ferriss' podcast. I heard
you on that. I did, yeah. It was excellent.
I did, yeah. Like three of them, I think I did. I've been on for three. Three,
really? Oh, I need to listen to the other two then.
What is this wine you brought me, man? This is crazy. That is... Do you think I'm
a drunk? Is this what this is?
Maybe the dry farm wines guys think that... This is a giant magnum. I'd have to
have a party.
It's a wine that's pretty legit in regards to if you want to stay on a ketogenic
diet.
Yeah. And I tested this in my office, actually, and just found that it's non-glycemic,
for one thing,
which means it doesn't impact... The sugar content is so low, there's not an
elevation in blood glucose,
and I can stay in ketosis on this wine. If I do one glass, two or three starts
to kick me out,
but two glasses of wine, you can completely stay in ketosis.
Interesting. Most glasses, most wine, will kick you out of ketosis?
Yeah, I mean, it's highly dependent on... Like a Merlot, a dry wine typically
doesn't, but a sweeter wine...
Is Merlot more dry?
Most of it, yeah. Most of the time, yeah.
But white wines tend to kick me out more, and of course, something like a sweet
wine will kick you out.
Like a Riesling or something like that.
Yeah.
Really sweet wine.
Sangria, you know, that'll kick you out very fast.
Oh, yeah. That's just sugar, yeah.
And even beer does. Even though it's supposed to be low-carb, beer tends to
kick me out.
Really?
Make a low-ultra, maybe one, you know, one or two. But other than that, yeah. I
mean, I get that question a lot.
So it actually got me interested into studying this, so I can answer some of
the questions with some level of knowledge.
And after testing these wines, I came to the conclusion, yeah, you can drink
two glasses of wine a day on a strict ketogenic diet.
And, I mean, this is important for, you know, people that are doing it to
manage their health long-term.
Right.
Especially people with actual health issues where ketogenic diet benefits them,
like epileptic.
Absolutely. Like, when I got into this, it was pediatric epilepsy, like in 2007
or 2008.
And now the applications are expanding, you know, a dozen or more.
So we hold a conference, a metabolic therapeutics conference, where top-tier
people in academia and, like, from Johns Hopkins,
they're probably one of the spearheaded ketogenic diet application clinically.
And top-tier scientists, like from Yale and Harvard and other places, present
here.
And it's, I think, it was like 11 or 12 applications for the ketogenic diet
where there's good peer-reviewed,
research to support the efficacy as a metabolic-based therapy for a number of,
everything from, you know,
polycystic ovary syndrome to acne to rare, even genetic disorders, like Angelman
syndrome is something that we're studying.
It's a genetic disorder where a house-keeping gene is mutated and it results in
seizures and motor function impairment.
And the ketogenic diet is remarkably effective.
It's really drug-resistant seizures that these kids have.
And even in the presence of a persistent molecular pathology, a genetic pathology,
the ketogenic diet, through altering metabolism with the ketogenic diet,
you can largely silence the pathology and the motor function impairments
associated with this disease.
And that's amazing to me that you have a disease that is persistently there due
to a genetic mutation,
and you can largely silence the symptoms, the seizures.
In the interest of addressing people that are probably on the ground floor,
and I feel like there's very few people today that don't understand what a ketogenic
diet is, but just in case.
For people who don't know, there are people that use carbohydrates mainly for
fuel,
and then there's the ketogenic diet, which makes your body run on fats and ketones.
So just kind of explain that to people, like how this came about, how people
started researching this,
and how you got involved.
Okay.
I mean, this goes back, if not centuries, like millennia, you know,
dating back to the time of Hippocrates when it was observed that fasting was a
quote-unquote cure for seizures.
And with the observation.
Yeah.
So fasting puts you into fasting ketosis, right?
So even intermittent fasting, like I do the 14-hour thing.
Right.
14 hours, you know, that's clinically.
I mean, technically, that's kind of, I call that a semi-fasted state when you
achieve that.
You know, when you're eating breakfast, it could be, you know, 12 hours or more
since you've eaten last,
and you're breaking the fast, essentially.
But with severe epileptic patients, it was found that when they restricted food,
and in some cases water, after about two or three days, you had profound
seizure control,
where it silenced even the worst seizures.
And this was observed, you know, for millennia, like I said.
And there was some work done in the early 1900s and 1920s, there was some work
done at the Mayo Clinic that observed the presence of these ketone bodies
in people that were eating a carbohydrate-restricted diet that was primarily
based on eating fat,
and with a minimal amount of protein, just enough to ensure there was not
protein, you know, malnutrition.
And it was observed that there was an elevation of ketone bodies, beta-hydroxybutyrate
and acetoacetate in the blood.
So they called it, physiologists called it the ketogenic diet.
Even technically, maybe beta-hydroxybutyrate's not a ketone, but physiologists
called these ketone bodies beta-hydroxybutyrate, acetoacetate, and acetone.
And it mimicked the physiological state of fasting in many ways.
So if you were to draw blood off someone on a ketogenic diet, it would sort of
look like they had been fasting a few days
because it's mimicking, the way I think about it, it's suppressing the hormone
insulin
and kind of mimicking the fuel, the substrate utilization that you would be
using in a state of being fasted,
which is primarily fats, ketones, and to a lesser extent, glucose from amino
acids, from protein.
You are mobilizing some gluconeogenic amino acids from your skeletal muscle
when you are fasting.
Ketones are protein-sparing, though, so they are anti-catabolic in that way.
So because we make ketones, and our large brain has a massive demand for energy,
and the ketones fulfill that for the most part when fasting, it prevents us
from breaking down muscle.
It prevents us from liberating the gluconeogenic amino acids that would
otherwise, you know,
be chewed up and used to maintain our glucose levels.
So the ketones sort of replace glucose.
The brain has the metabolic flexibility to adapt from using glucose to using
primarily ketone bodies.
And those ketone bodies really have a protein-sparing, anti-catabolic effect.
Now, is this an ancient system that was in place back when people, you know,
obviously couldn't go to the store, and your diet varied depending upon what
was available,
and it just allowed people, like, say, like, maybe Inuits that lived off a lot
of fats
because they really don't have many carbohydrates if you're living off a whale
blubber
and things along those lines like they had to back then?
Yeah.
I mean, it's hardwired in humans and obviously in other animals.
My wife studies manta rays, and they're like the Einsteins of the sea.
So they're the fish with the biggest brains of all animals,
and we've done metabolomic studies on them and looking at the blood,
and they produce a significant amount of ketones, like 2 millimolar.
They dive really deep, so it may help protect them from that.
So, yeah, animals will go into ketosis during fasting or even if you manipulate
their food source.
The Keto Pet Sanctuary actually treats dogs that have cancer,
and they implement a ketogenic diet in dogs in addition to some other things to
help.
And many of these are dogs taken from kill shelters and put them on an anti-cancer
therapy program,
and they can get into ketosis.
For the most part.
Most dog food is not ketogenic.
It's like dog foods have grain in it, right, for fillers and things along those
lines.
Yeah, it's really interesting.
I was talking with Ron Penna yesterday from Quest Nutrition, the CEO of Quest
Nutrition,
and he brought to my attention that if you look on a package of dog food, you
won't see carbohydrates listed,
even though it's the primary because there was some laws or policy put into
action
to prevent carbohydrates from even being listed on kibble, on dog food.
Why?
Which I find, you know, there's a lot of reasons why.
Mostly because dogs really shouldn't be eating a carbohydrate-based diet,
and that's probably part of the reason, but there's sort of other reasons why.
But it's really important that, so the food that the Keto Pet Sanctuary gives
the dogs that have cancer,
and they confirm that they have cancer with a glucose PET scan, and they do it,
you know, before, during, and after,
is basically kind of like a raw foods, ketogenic diet that's almost completely
restricted in what we would call glycemic carbohydrates,
things that would elevate the glucose levels.
And it's very high in fat, relatively speaking.
Yeah, but dogs, you know, really should not be eating any kind of grains at all.
Yeah, I feed my dog grain-free dog food, but I don't know if it's carb-free.
I don't know what's in there.
Is it kibble?
Yeah, it is kibble.
It's hard to find out.
Right, yeah.
I mean, you know, dog food that has, like, some peas and sweet potatoes and
things like that is okay.
But ideally, you know, you want to give your dog, like, a whole food nutrition,
just like humans.
You know, they say don't give your dog human food, but that's, there's no
evidence for that.
And, you know, I've given talks where I talked about giving dogs raw food,
and there'd be a reaction from the audience, well, it's dangerous to give your
dog, like, raw food.
Well, what do they eat in the wild, you know?
I mean, if it's ground beef that's been sitting around in a processing plant
for a while, yeah, maybe.
But fresh, you know, meat from a butcher or fresh meat, I mean, it's probably
the ideal thing for a dog.
Ideally, organ meats, like liver, heart, kidneys, things like that, grinded up,
you know, and some greens, too.
And things like spinach, you can buy, like, spinach powder.
So the Keto Pet Sanctuary has an e-book that's completely free if you go to ketopetsanctuary.org,
I believe.
And you can download its e-book, and it tells you very precisely how to make
your dog food,
not only to, you know, if your dog gets cancer, but to maximize its overall
performance.
And you are preventing cancer by virtue of putting them on a diet that optimizes
their metabolic health.
Well, that's got to be very difficult to package, though, in something that's
sort of evergreen.
It sits on the shelf in a paper bag you can rip open and just pour into a bowl.
That's what everybody wants.
It's like this convenience thing.
There's a way to do it, and, you know, I know those guys, you know, Epigenics
Foundation, they are working.
They basically support the Keto Pet Sanctuary, and they're working out not only
the macronutrient ratios that need to go into the food,
but also the types of food and also being able to package it in a way to
ultimately come up with a food that you can go.
It may not be on the shelf, and probably ideally shouldn't be on the shelf, but
it'll be, like, in the refrigerator section of your pet food store.
So you go there, and, like, for our dogs, we get, like, a tube of freshly
ground-up steak or whatever, and we feed that.
We take, you know, the ground meat and mix it with Oregon meat and mix it with
different greens, like broccoli and things like that,
and give it to them, and they love it.
We put a little bit of coconut oil on it sometimes.
So you would go to the grocery store, or it would be, could be shipped to your
hou