Name: Joe Rogan Experience #1683 - Andrew Huberman
Uploaded: 2021-07-14T00:00:00.000Z
Description: Watch the stand-up comedy video 'Joe Rogan Experience #1683 - Andrew Huberman' from PowerfulJRE on Comedy Buff. Published 2021-07-14. Transcript available.

Watch the stand-up comedy video 'Joe Rogan Experience #1683 - Andrew Huberman' from PowerfulJRE on Comedy Buff. Published 2021-07-14. Transcript available.

Joe Rogan Experience #1683 - Andrew Huberman

Joe Rogan podcast check it out the Joe Rogan experience train by day Joe Rogan
podcast by
night all day yeah anyway I'm just a giant fantasy VD I use it constantly yes
it for
like I use the roll-ons for muscle aches and I use gummies and and CBD MD is
one of my sponsors but
this uh Kill Cliff Company this is a this is actually a drink that I designed
it tastes really
good thank you I like it yeah so many of the questions I get are about anxiety
people like
how do I control my anxiety if people are stressed so the CBD is supposed to
help with that it's
supposed to help with that and I think it does a little bit one things that I
found is a CBD with
THC it alleviates even more I can add a little THC to it yeah I can imagine
yeah THC probably takes
the edge off but it's also a balancing act you know the problem like I used to
get a CBD with THC from
a local company in LA and they were so inconsistent in that like I'd take like
I had a thing I'd do
like three droplets I'm like okay I got three droppers full and then one day I
did three droppers
and I was on the fucking moon I was like what are you what have you people done
street side chemistry
yeah they're all bathtub chemists well that's the thing the um I think with
supplements they're so
poorly regulated yeah I'm not pushing for regulation the last thing we need is
regulation on it but it's
like melatonin I was talking about Walker about this who you know sure friend
Matt amazing sleep
scientist and turns out that the amount of melatonin if it's listed like three
milligrams or six
milligrams it can vary anywhere from being 15 15 percent of what's actually
listed on the bottle
to 85 percent more and if you look at how much melatonin is actually made by
the pineal gland
it's a tiny fraction of the three milligrams it's supposed to be so melatonin
it's all over the place
does that mess you up if you if you take melatonin does your body say well I
don't need any melatonin
I don't need to make it it might the bigger I never suggest melatonin for sleep
for a couple reasons one
is the reason kids don't go into puberty until a certain age is because they
have chronically high
melatonin really melatonin suppresses puberty so does it suppress your endocrine
system so in humans
it's probably not as dramatic as it is in animals that are seasonal breeders
but long ago when I was a
graduate student at Berkeley we would do these experiments on these little what
are called
Siberian hamsters these little hamsters and these hamsters only breed in long
days because light
basically suppresses melatonin okay so in short days long nights seasonal
breeding animals shut down
breeding right humans can breed all year long of course but if you give melatonin
to a male
Siberian hamster its testes go from the size of standard marbles to the size of
a grain of rice
within a week wow and the females their ovaries involute they basically turn
into like little
shriveled not even raisins but little specks so when I hear about people taking
a lot of melatonin and
you've got this whole issue with falling testosterone dysregulated estrogen in
men and women
um I just think it's not the best sleep aid the other thing and Matt and I have
talked about this a lot
recently just we've been hanging out and chatting about science or as he would
say splashing around
in the science of sleep as you know he's a Brit after all um the problem with
melatonin is it will
help you fall asleep but it won't help you stay asleep and so some people have
this problem they take
melatonin they fall asleep and then they wake up three or four hours later it
wears off yeah there are
much better things for sleep what what do you choose for sleep yeah my favorite
sleep cocktail based on
really good solid peer-reviewed science is magnesium threonate it's t-h-r-e-o-n-a-t-e
threonate
and something called apigenin a-p-i-g-e-n-i-n which is basically a derivative
of chamomile
those two things work really well too they essentially shut down the forebrain
thinking
anticipating part of your brain allow you to drift off into sleep really well i
need that all day then
if you shut that down yeah well and then theanine is also that is the third
thing in the cocktail
isn't theanine uh that is also a nootropic so theanine uh also turns on what's
called the gaba
system it's like an inhibitory neurotransmitter and it helps suppress anxiety
and kind of turn off
thinking it helps you make the transition into sleep yeah so it's magnesium threonate
i'm gonna write
sure thing because i think i do need this yeah and sleep is pretty good but it's
always these are a game
changer i'll be amazed if it doesn't help so it's magnesium three and eight t h
r e o n a t e
and that's important because there are a lot of t h r t h r e o n a t e e o n a
three and eight
he's got it right there there it is young jamie on the ball as always and
basically you know people
will probably want to know about source in this case you just go for price
right i mean go for
if you have a favorite brand go for that but go for price you know so um
magnesium three and eight
can cross the blood brain barrier because when you take magnesium it goes into
your gut doesn't
necessarily get into your brain you've got a barrier around your brain that
prevents certain things from
getting in because this tissue doesn't regenerate right so the three and eight
form has a gets brought
across the blood brain barrier by a transporter other forms like magnesium malate
magnesium citrate
those are good for other things magnesium malate is great for muscle soreness
magnesium citrate is a
great laxative but uh magnesium three and eight is going to be the one that's
going to allow you to
drift into sleep better you know it's interesting that you're saying this
because uh one of the
things that i've found that relaxes me more than anything is uh epsom salts you
know um i'm a big
proponent of the isolation tank and the sensory deprivation tank is all filled
with magnesium it's all
filled with with epsom salts and it can go transdermal yeah so that's a really
unusual situation where if
you you know you get and there are some magnesium creams and things like that
but you're not going
to get it in the kind of volume that you get it when you lie in it like that
and when you're doing
that what what magnesium is that so that's usually a magnesium by glycinate
which is another one of
these forms of magnesium that can get transported into the brain really easily
and most people actually
are magnesium deficient i think um most people could would do well by
increasing their magnesium
intake i supplement but i think i supplement with citrate yeah so citrate has
its value malate again
it's good for muscle soreness but three and eight what you want to take is
about 300 to 400 milligrams
but what you'll notice is on the bottle it'll say elemental magnesium and then
magnesium will be 300
to 400 and then it'll say equals 1000 milligrams basically just go for 300 to
400 milligrams and
you're good and then the other thing is apigenin a-p-i-g-e-n-i-n and this stuff
is terrific
it basically that's the only source i'm aware of oh this is like a cocktail
yeah and i should be very
clear that uh maybe because i've been blabbing about this how is this uh this
cocktail put together
did you just put this together so i want to be really clear i have no
relationship to these brands
or anything okay um i've been blabbing about this on my podcast oh that's why
and so someone is clearly
gonna making money out of the amazon partnership thing or whatever that's what
they put it but
those are the three things well i bet a bunch of people just started buying it
together because
it's just this is just frequently bought together right so those are the three
that i recommend
and then l3 and and so for apigenin it's 50 milligrams women see the prostate
health thing and
they freak out 50 uh women see prostate health thing and they freak out well
they think oh is it
testosterone for guys yeah whereas all the the gym rats are like testosterone
yeah they get excited
bro um so apigenin turns on a chloride channel the way neurons work is you got
stuff going in and out
of them and the chloride channel tends to turn off neurons a little bit in a
good way and creates a
kind of a little sedative role uh it kind of helps you drift off into sleep and
it's the same stuff
that's in chamomile tea so this has no negative uh side effects for women not
that i'm aware of oh i
hate that term well you know okay so i know a number of people including women
that use it
and are fine are still fertile you know i don't know i mean i haven't tested
their their fertility
personally what is the idea of it the what the benefits for prostate health so
it does seem to
have a small amount of estrogen antagonism it can block estrogen receptors a
little bit but it's a
very weak affinity maybe calm some ladies down i said that we could not not mr
huberman thank you
well just a joke years ago stop screaming years ago i worked on hormones and
development
we could we could go there hormone effects on the brain uh that was my master's
thesis but the um
but theanine t-h-e-a-i-n-e is also has a little bit of an anxiolytic and anti-anxiety
effect
and there is something to think about with theanine people now put theanine in
energy drinks
so that people will drink more energy drinks and not get the jitters
interesting and so it's uh it's
showing up i recommend taking these 30 to 60 minutes before sleep and what do
you recommend for a dose for
for theanine it's going to be 100 to 400 milligrams however if you're a sleepwalker
or you have what
are called night terrors where you have really disturbing dreams leave the theanine
out because
the dreams on theanine are intense really i like them but it's intense but i'm
into dreaming i think
dreaming is a really interesting i think theanine is in uh that neuro gum isn't
it young jamie yeah
i think it's in there they're putting it in everything now the one thing about
magnesium
threenate i should mention is that there are some data not a ton that it's also
neuroprotective
so there's at least one study peer-reviewed independent you know not not a
company paying
for the study but done by a laboratory with no bias that shows that magnesium
threenate can offset
some forms of atrially cognitive decline so that's also that's another reason
to so the cocktail of
the three of them the reason for putting the three of them together there seems
to be some sort of
synergistic effect because some people of course will will take something for a
long period of time and
then it'll stop working you can take these they're not habit forming i mean i've
taken them consistently
and then taken breaks and then go back on them and they really in most cases i
mean i guess if someone
had a heart condition a serious heart condition anytime you mess with magnesium
because you have
neurons in your heart magnesium is involved in neuron function you obviously
the usual things check with
your doctor you know and obviously i'm not a doctor and professor so i profess
things i'm not
prescribing anything but uh it's helped a tremendous number of people get into
sleep better and stay asleep
interesting and i i think walker would would generally agree i can't speak for
him he's really into all
this new like i don't want to take away his next kind of he's planning some
really amazing public
education stuff i've pulled him into the mix he freaked a lot of people out on
my podcast well he
scared people a bit yeah yeah so we talked about that i mean like i think first
of all that was an
important podcast it just what it wasn't just a brilliant podcast it was
important because people were
ignoring sleep we heard be a heart go hard driving hard driving hard driving
and it's
very important that people understand that the fundamental layer of health
mental health and
physical health is regular quality sleep so he scared people appropriately i
thin