Name: What Happens in the Brain During Addiction
Uploaded: 2021-09-16T17:12:02.000Z
Description: Watch the stand-up comedy video 'What Happens in the Brain During Addiction' from PowerfulJRE on Comedy Buff. Published 2021-09-16. Transcript available.

Watch the stand-up comedy video 'What Happens in the Brain During Addiction' from PowerfulJRE on Comedy Buff. Published 2021-09-16. Transcript available.

- The Joe Rogan experience.
- It's something that people used to call
the addictive personality.
We don't really call it that anymore.
We just use the idea of the disease model.
So we say that somebody has the disease of addiction.
It's a chronic relapsing and remitting problem.
People come to it with different degrees of vulnerability.
And the risk for it can essentially be summarized
as nature, nurture, and neighborhood.
And just to briefly describe that,
if you have a biological parent or grandparent with addiction,
you are at increased risk compared to the general population
of getting addicted yourself.
If you have a co-occurring mental illness,
you are at increased risk of getting addicted.
If you have certain character traits,
like you're more impulsive,
you have a hard time putting a break between the idea
to do something and actually doing it,
you're at increased risk for addiction.
So that's kind of all in the sort of nature risk category.
There's also the nurture piece of it.
So if you grow up in an environment where you experience
a whole lot of trauma,
you are at increased risk for becoming addicted.
If you grew up in an environment where your caretakers model
using drugs and alcohol or other addictive substances
or behaviors as a coping strategy,
you are at increased risk of becoming addicted,
or even if they just implicitly condone it.
And then that brings us to the whole neighborhood idea.
And this, I think, is a really under-recognized aspect
of our risk for addiction, which is just simple access.
So if you live in an environment where you have more access
to highly reinforcing drugs and behaviors,
you're more likely to try them and just simply in being exposed,
especially with the increasing potency, variety,
and novelty of drugs today,
you're at increased risk of becoming addicted.
So if you go see a doctor who's more free with their prescription pad,
you're exposed to opioids or benzos,
you're more likely to get addicted.
If you grow up in a culture where people are playing a lot of video games,
you're more likely to try them, more likely to get addicted.
And so this nature, nurture, and neighborhood are the risk factors.
But again, people bring different degrees of vulnerability
to this problem of addiction.
And some people are more vulnerable than others.
And you may indeed be in that category,
where you're just somebody who, you know,
once you find something that's reinforcing for you,
you just go, vroom!
And you just want to do it again and again and again.
- When you say reinforcing, what do you mean by that?
- I mean that it's rewarding in some way.
- Rewarding.
- Rewarding, right.
So it's pleasurable at first.
Now, the thing about addiction and the way that it changes our brains
is that that thing that initially is pleasurable
and has us engaging in approach behaviors,
if we continue to consume that substance or engage in that behavior,
it ultimately actually puts us in a dopamine deficit state
such that we want to continue to do that behavior,
not to feel good, but just to stop feeling bad.
And that's kind of one of the fundamental things
about the disease of addiction.
It's innate vulnerability to start,
added to the changes that occur in the brain
as a result of ongoing consumption of our drug.
And those brain changes are what drive continued compulsive use.
- So that's the difference between being enthusiastic
about something that you enjoy versus something that consumes your life.
So you're kind of chasing the dragon, like the initial for,
like, that's what they talk about it with heroin addiction, right?
- Right.
- Don't they say chasing the dragon?
- Yeah.
- The initial rush that you get from the first uses of it,
you're always chasing that.
But really what you're doing later on in life is just trying to not be sick.
Not having it in your body makes you feel terrible.
- Right.
So, so interesting that, that term chasing the dragon,
it comes in part from, as you describe,
like the elusiveness of trying to recreate that initial high,
which with continued use becomes harder and harder.
But it also literally comes from when heroin is inhaled.
So if you put it on a piece of tinfoil and you light it underneath,
you get this kind of smoke and then that plume looks like a dragon's tail.
So it's got a couple of different meanings.
But yes, I mean, what you're saying is exactly right.
And the way that I describe this to patients and describe it to medical
students is,
imagine that in your brain there's a balance,
kind of like a teeter-totter in a kid's playground.
And one of the most interesting findings in neuroscience in the past 75 years
is that
pleasure and pain are co-located, which means the same parts of our brain that
process
pleasure, also process pain, and they work like opposite sides of a balance.
So when we do something that's rewarding or reinforcing or pleasurable,
our balance tips slightly to the side of pleasure, we get a little release of
dopamine,
the pleasure neurotransmitter in that part of our brain, our reward pathway,
and we feel good.
But the thing about that balance is that it wants to remain level.
And the brain will work very hard to restore a level balance, or what's called
homeostasis.
And it does that by tipping the brain an equal and opposite amount to the side
of pain.
So again, the way the balance restores homeostasis is to tip to the opposite
side.
That's the come down after using that moment of wanting to do it again, the
hangover.
If we wait long enough, that feeling passes and balance is restored.
But if we don't wait, and we continue to use our drug again and again,
we end up with a balance that's essentially weighted to the side of pain.
And I imagine that like these little neuroadaptation gremlins hopping on the
pain side of the balance.
It's not very scientific, I know.
But the point is that with repeated use,
we get enough gremlins on the pain side of the balance to fill this whole room.
And then we're essentially working from a dopamine deficit state.
We've down-regulated our own dopamine.
We've down-regulated our own dopamine transmission.
And those gremlins like it on the balance.
So they don't get off after the hangover is over or the acute withdrawal.
They can persist there for weeks to months to years,
which is why people with addiction, even when their lives have become so much
better,
will relapse because they're not walking around with a level pleasure pain
balance.
They're walking around with a balance tipped to the side of pain.
They're experiencing the universal symptoms of withdrawal from any addictive
substance or behavior:
anxiety, irritability, insomnia, dysphoria,
and intrusive thoughts of wanting to use their drug again.
Now with enough time elapsed, and again, with people in people with severe
addiction,
it can take months to years, those neuroadaptation gremlins will hop off.
We will regenerate our own dopamine and our own dopamine receptors,
and our level balance or homeostasis will be restored.
Is it scientific to call them gremlins?
Super scientific.
Watch the entire episode for free only on Spotify.