Name: Joe Rogan Experience #2278 - Chase Hughes
Uploaded: 2025-02-25T18:00:24.000Z
Description: Watch the stand-up comedy video 'Joe Rogan Experience #2278 - Chase Hughes' from PowerfulJRE on Comedy Buff. Published 2025-02-25. Transcript available.

Watch the stand-up comedy video 'Joe Rogan Experience #2278 - Chase Hughes' from PowerfulJRE on Comedy Buff. Published 2025-02-25. Transcript available.

Joe Rogan Experience #2278 - Chase Hughes

Joe Rogan Podcast, check it out!
The Joe Rogan Experience.
Train by day, Joe Rogan Podcast by night, all day!
Good to see you.
We're debuting these mugs.
My friend Turkey Merc on Instagram sent me these Cheshire Cat mugs.
Isn't that badass?
Yeah, that's really good.
I thought it'd be good for you, because we're talking about mind fucks.
Cheshire Cat's a little bit of a mind fuck.
In the simulation.
Yeah, for sure.
So you were just telling me that you had a brain disease.
And what did you do to fix it?
What was it, first of all?
It's temporal epilepsy with mesial temporal sclerosis.
And when did you develop this?
We don't know, but I started having seizures like a few years ago.
And everybody in my family knows I'm a neuroscientist.
I'd say with a lowercase n, not a PhD neuroscientist.
But you studied neuroscience.
Yeah.
I had post-grad at Harvard and Duke.
But they assumed, you know, Chase has studied all this stuff.
He's going to know if he's having seizures.
But these seizures come with amnesia.
So I didn't remember that I was having any of them.
And this was like three years ago.
I had retired from the military and then started having these seizures.
So then I found a neurologist.
The drug that they gave me, the number one side effect was seizures from this
pharmaceutical company.
So I kind of looked around and I found this guy is a functional medicine guy.
And he got me on methylene blue to start off.
And I know Mel Gibson was on here talking about it.
And that instantly stopped everything.
And some other stuff.
That stuff was a fabric dye, right?
Yeah.
In 1890.
How weird.
And it, who the fuck drank it first?
Who's that guy?
Make blue jeans out of that?
Huh?
What would it taste like?
Yeah.
What if I drink it every day?
If it affects my health?
It tastes like chewing an aspirin.
I'd take it.
Okay.
Yeah.
I'd take it every day as well.
Yeah, RFK Jr. told me about it.
Yeah, man, it's fantastic.
And so this guy's injecting, in 1890, injects these rats with it.
And then does an autopsy on these things.
And their brain, their brainstem, every single nerve is blue.
So he discovered this methylene blue has an affinity for neuronal tissue.
So he says, well, it's sucking into neurons.
What's it doing?
So we could talk about it if you want to.
Sure.
How it's working and working in the body.
So we started putting it in humans.
And we found out it's an MAOI, which is just...
Monoamine oxide inhibitor.
Yeah.
Yeah.
Which helps with depression and anxiety.
And all kinds of life stress and stuff.
Does it cause side effects if you're taking any drug that you shouldn't take
with an MAOI?
There are some studies that have been recalled that said you can't take it with
SSRIs because you could develop serotonin syndrome.
Right.
But they did recall the studies as far as I'm aware.
And it is so incredible that it acts as an electron donor to mitochondria,
especially your neuronal mitochondria.
So it helps you produce more ATP and it helps you get rid of this stuff called
reactive oxygen species.
So you have an oxygen molecule that should have two hydrogens on it.
And like your body's job is to convert stuff into water so you can pee it out.
So if you get an oxygen molecule, it's got four, five, one.
It's a reactive oxygen, which we call free radicals.
So methylene blue goes in there and balances a lot of those things out in your
brain and your nervous system.
So it is a miracle and it's been proven for 100 years.
It's one of the most well-proven drugs out there.
What's the side effects of it?
Are there any?
Not a bunch.
I would imagine if you're taking an MAOI, there's wild shit going on there.
Yeah.
Like if you mix it with anything that has metyramine in it, like aged cheeses,
red wine, you're not supposed to mix it.
If you're on a high dose, though, but you're probably taking one milligram per
kilogram and you weigh probably 75 kilograms.
What's that weight?
What's 75 kilograms?
You're probably 189, 190?
Close.
Okay.
Yeah, pretty close.
A little heavier than that.
Okay.
And so you take maybe 40 milligrams a day to 80 milligrams a day.
And you put it in water?
Is that what you do?
No, I have these little trokes.
It's like the consistency of a starburst.
Oh, okay.
And you just cut them up and they're 40 milligrams each.
You obviously got to swallow them really quick or your teeth are going to be
blue for an entire day.
Yeah.
Yeah.
It's a pretty potent dye.
I see it in my pee.
Yeah.
Well, I had to change the toilets in my house to black toilets because my kids
take it.
My wife takes it.
Jesus.
Everybody takes it.
But like if you go to a party and you forget to flush, everybody just thinks
that there's blue stuff in it.
It's one of those supplements that I take.
I'm like, are you sure?
Like every time I take it, I'm like, are you fucking sure?
Like I drink it in water.
I take a little eyedropper and I squirt it in water and I drink it.
No, Gary Brecca told me about it.
I should correct that.
He told me to take it with red light therapy.
That's what it was about.
Did he tell you why?
Why it all works?
He probably did, but I probably forgot.
Why does it work for red light therapy?
So anything that's blue means that it absorbs red and reflects blue light.
So if you're in a red light therapy machine, all your neurons are soaking up
way more red light than they otherwise would without methylene.
So it's fantastic.
It's like 600x the effectiveness of red light therapy.
Really?
I'm making that up, but it is a significant.
Sounds good.
Yeah.
It's a significant increase.
How weird is it to be essentially a brain expert and get a brain disease?
It was horrifying because I know where this is going to go.
At the end of the day, your hippocampus, your memory center of your brain is
eating itself.
And during a seizure, you can lose up to about a million neurons a second.
And the seizures were like a minute and a half long.
And they're not like shaking on the floor.
A temporal lobe seizure, you're just kind of like, you're just out.
Like you're unconscious.
Seize up like Mitch McConnell.
Yeah.
Like you turn into a little zombie, your head falls down.
And at the end of the day, I tried so many different things to fix it and stop
these seizures.
I was at a point of nine seizures a day.
Jesus.
And I was desperate.
And you think this is because of the medication that they gave you that caused
the seizures?
Or is this just a...
I never took it.
Oh, okay.
So you had seizures.
But the medication...
Why would they give you something that has a side effect of seizures?
I don't know.
If you're getting seizures.
And I don't know why they're...
I mean, you hear so much about these medical schools getting paid off by
companies and stuff
that don't really have our best interests at heart.
And I think that methylene blue, it's...
You shouldn't have to tell a doctor about methylene blue.
I think everybody should know about it.
And you can get it on Amazon.
You can get it...
I get mine from this company called MitoZen.
And it's fantastic.
And it's changed my life.
I would have been gone by now.
What's the root cause of this disease?
Do they know?
Do they know what's going on?
So there's one...
There's two factors.
You have a genetic predisposition.
So you have this thing in your genes called the APOE4-allel.
Okay.
That's the same thing that causes you to get CTE.
And yeah, Alzheimer's.
Yeah.
And if you have that...
I shouldn't say causes you, but...
Yeah.
You know, it's one of those ones where if you get hit in the head a lot, it's
not a good
thing to have.
Right.
And then I did 20 years in the military.
So being around explosions and all kinds of gunfire and all that kind of stuff,
they
said this probably caused some kind of concussive syndrome.
Yeah, that's a real issue, right?
People think of concussions only as like you getting hit, but it's not.
It's any kind of jolting to your body.
Yeah.
My friend Mark Gordon works with a lot of soldiers and people with traumatic
brain injuries, and
he says you can get it from jet skiing, which is really crazy.
Wow.
Just the bounce?
Mm-hmm.
I had no idea.
The hard bouncing, the jostling.
If you like people who really love jet skiing and do it all the time, they
start getting a
little bit of CTE.
That makes sense.
Our brain is floating.
It's neutrally buoyant inside of liquid.
Yeah.
That makes sense.
Yeah.
It's smashing around inside your skull.
All right.
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So how did you get involved in, I mean, your space is like you wrote this book,
Behavior Ops
Manual, and you've got a lot of stuff online, like how to motivate yourself and
discipline
yourself.
And that's how I found out about you.
Some of the different videos that I thought were really insightful about how to
sort of
schedule, progress in whatever you're trying to accomplish in your life, how to
set things
out.
How'd you get involved in all this kind of stuff?
It's a story.
I mean, I was 19 years old, stationed in Pearl Harbor.
I got turned down by a girl one night, and I went home and I typed in how to
tell when
girls like you on the internet.
I printed out like a two foot stack of shit just to read through because I didn't
want
to be rejected again.
So that's hilarious.
I got into this body language stuff and then it was just behavior.
And the more I could kind of see somebody's insecurities and when somebody was
stressed and the little
fears that are hiding behind behaviors, like it made them human to me.
So I think I had some social anxiety and me being able to kind of see behind
that mask.
I wasn't judging anybody, but it was like, wow, they're messed up too.
So I kind of got addicted to that.
And I just rode this line down this behavior path and I got obsessed with
studying all this
behavior.
And a friend of mine was killed on USS Cole during the terrorist attack in 2001.
September 11th, the coal got attacked in the Gulf of Yemen.
And I was like reading these intelligence reports afterward that said, there's
failures on
the ground.
We didn't develop assets in the country.
We didn't take the actions that we needed to take to get this intelligence.
And I was like, man, they need this behavior stuff.
So I got more and more obsessed with it.
And I started training people in the government probably around the age of 30
or so.
And that was like just a few years before I retired at 38.
And the novelty still hasn't worn off for me.
I'm still obsessed with that field of study.
So were you trained to train people?
Like how did you go about starting to train people?
What was it based on?
It was me.
The first group of people I trained was a car dealership just to see if I could
do it.
I said, I'm going to go in there and do it for free.
And then I started training people in the military.
And these are U.S. Navy and other branches.
And I'm training them in like these.
I got obsessed with this interrogation stuff and how the brain works.
And I got mostly got obsessed with if I'm an intelli